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Home Therapy Infections in HIV / cellular immune disorders

pneumocystis jirovecii pneumonie

Advices

≥ 18 years
Priority Medication Remarks
Priority:
 1st choice 		Medication:

cotrimoxazol (trimethoprim +sulfamethoxazol) iv 1920mg 3dd 14 days
Remarks:

milde gevallen eventueel per os
Priority:
 1st choice alternative 		Medication:

cotrimoxazol (trimethoprim +sulfamethoxazol) iv 1440mg 3dd 14 days
Remarks:

gewicht < 50 kg

milde gevallen evt. per os
Priority:
 2nd choice 		Medication:

clindamycine iv 600mg 3dd 21 days

+

primaquine po 30mg 1dd 21 days
Remarks:

bij overgevoeligheid co-trimoxazol

G6PD deficiëntie uitsluiten voor primaquine
Priority:
 3rd choice 		Medication:

atovaquon po 750mg 2dd 21 days
Remarks:

suspensie, innemen met voedsel; alleen bij niet ernstige PCP
Priority:
 4th choice 		Medication:

trimethoprim po 300mg 3dd 21 days

+

dapsone po 100mg 1dd 21 days
Remarks:

overgevoeligheid co-trimoxazol
Priority:
 4th choice alternative 		Medication:

pentamidine iv 4mg/kg 1dd 21 days
Remarks:

laatste lijn

General comments

Bij pO2 < 70 mm Hg of 8-9 kPa toevoegen prednison:

dag 1-5 2 dd 40 mg;
dag 6-10 2 dd 20 mg;
dag 11-14 1 dd 20 mg

Na behandeling secundaire profylaxe

Bij G6PD deficiëntie ook oppassen bij dapsone en co-trimoxazol. 

Sources

Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources
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Metadata

Swab vid: G-500310.1
Updated: 08/31/2021 - 13:31
Status: Published